People with immature or suppressed immune systems, such as newborns, transplant recipients, or people with AIDS, are prone to severe complications from HSV infections.
HSV infection has also been associated with cognitive deficits of bipolar disorder, and Alzheimer's disease, although this is often dependent on the genetics of the infected person.
HIV/AIDS, immunosuppression in solid organ transplants). Neonatal herpes simplex is a HSV infection in an infant.
It is a rare but serious condition, usually caused by vertical transmission of HSV-1 or -2) from mother to newborn.
Herpes simplex virus 2 is typically contracted through direct skin-to-skin contact with an infected individual, but can also be contracted by exposure to infected saliva, semen, vaginal fluid, or the fluid from herpetic blisters.
To infect a new individual, HSV travels through tiny breaks in the skin or mucous membranes in the mouth or genital areas.
During immunodeficiency, herpes simplex can cause unusual lesions in the skin.
Symptoms include fever, headache, sore throat, and swollen glands. A herpetic infection of the brain thought to be caused by the transmission of virus from a peripheral site on the face following HSV-1 reactivation, along the trigeminal nerve axon, to the brain.
The appearance and distribution of sores in these individuals typically presents as multiple, round, superficial oral ulcers, accompanied by acute gingivitis.
Adults with atypical presentation are more difficult to diagnose.
The virus interacts with the components and receptors of lipoproteins, which may lead to its development.
Herpes transmission occurs between discordant partners; a person with a history of infection (HSV seropositive) can pass the virus to an HSV seronegative person.